A research team led by investigators at McMaster University has identified an axonal guidance signaling pathway that cancer cells use to infiltrate the brain. The combined results of preclinical in ...

A cross-sectional image of the mouse cerebral cortex in enlargement. The same method was applied as in the ferret. The cerebral cortex is shown in blue and some neurons are dyed green with GFP. In ...

Neurotrophins are essential proteins that support the growth, survival, and differentiation of neurons. Among these, brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal signaling ...

The neuron’s inner scaffold, once viewed as static support, now looks like a gatekeeper. Research findings are available ...

A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University. The research also ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein.

Within the human brain, movement is coordinated by a brain region called the striatum, which sends instructions to motor neurons in the brain. Those instructions are conveyed by two pathways, one that ...

New research identifies the SNAP-47 protein as the key regulator of slow oxytocin release, maintaining the brain's "social vibe." ...