A growing body of research has identified a hidden immune defect, not written in DNA, that helps explain why certain people develop life-threatening COVID-19 while others barely notice the infection.

Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders.

Interferons (IFNs) are a group of cytokines that were first identified in 1957, where they were found to interfere with a viral infection. IFNs possess several important properties, including ...

Despite potential benefits, the therapy remains in limited use for myeloproliferative neoplasms (MPNs). Pegylated interferons are a meaningful therapeutic option for the treatment of ...

Orozco said that while PTPN22/PEP in myeloid cells doesn't regulate type 1 interferons, it may play a role in other important immune signaling. "The point of this paper is to clarify what PTPN22 is ...

Over the past 35 years, interferons have been explored in various formulations for the management of Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), such as essential ...

Researchers have examined five SARS-CoV-2 variants to determine how each strain interacts with the innate arm of the immune system -- the first line of defense in the immune system versus the antibody ...

Your body makes interferons naturally. Three forms -- alpha, beta, and gamma -- control the activity of your immune system. But doctors also can use a man-made ...

Over the past decade, the pharmaceutical pipeline has become packed with small molecules that treat the hepatitis C virus (HCV). Hopes are high that the current standard of care—a combination of ...