Membrane protein targeting and insertion is a fundamental process in cellular biology that ensures proteins are correctly delivered to, and integrated within, the lipid bilayer. Proteins destined for ...

A recent review article highlights evolving MS-based methodologies that are reshaping ligand discovery and mechanistic characterization for membrane protein drug targets. LCGC International spoke to ...

(L to R) Corresponding author Hongbo Chi, co-first author Sujing Yuan and co-first author Renqiang Sun, PhD, PhD, St. Jude Department of Immunology. (MEMPHIS, Tenn. – March 19, 2025) Targeted ...

Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, a new study demonstrates how some cancer cells use the protein ...

Johns Hopkins scientists reveal that “inactive” GluD brain proteins regulate neuronal communication and open up new ...

For the first time, researchers identified the function of the CASKIN2 protein, which plays a key role in precise signal transmission between neurons and memory formation in the brain. This study is ...

Northwestern Medicine scientists have zeroed in on a cellular gatekeeper that may hold promise for treating abnormal protein ...

Study has combined genome-wide data with plasma proteomics from a Ugandan cohort to map hundreds of genetic regulators of ...

A newly identified mechanism lends credence to the idea that MS may be treatable by targeting EBV-infected B-cells, a study found.