When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

Over the past few decades, the idea of modifying a patient’s own immune cells to recognize and destroy cancer has evolved from concept to reality. So-called “adoptive T cell therapy” has emerged as ...

Transforming growth factor beta 1 (TGFB1), also known as TGF-β1, CED, DPD1, and TGFB, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein ...

Chugai Pharmaceutical has reported a new humanized antibody (Ab, SOF-10) that targets latent TGF-β1 and selectively blocks protease- and integrin αVβ8-mediated latent TGF-β1 activation.

For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once ...

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways. During liver regeneration, communication with organs such as the ...

Investigating the association of WNT pathway dysregulation and young-onset colorectal cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Gastrointestinal Cancers Symposium. This abstract does ...