A variant in the IL-7 gene may predict which patients with kidney cancer are more likely to experience side effects from immunotherapy. A gene linked to immune system function may help predict which ...

Please provide your email address to receive an email when new articles are posted on . Search engines and chatbots are easy to use. Databases such as gnomAD and ClinVar are comprehensive but come ...

Researchers found that paired pathogenic variants can restore protein function rather than make it worse. This phenomenon ...

An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource to identify those with a genetic risk for elevated "bad" cholesterol—a ...

For more than a century, Mendelian genetics has shaped how we think about inheritance: one gene, one trait. It is a model that still echoes through textbooks—and one that is increasingly reaching its ...

Citrate is a metabolite essential to the metabolism and development of neurons. A membrane transport protein called SLC13A5 plays a central role in this process and has previously been linked to a ...

I learned right away that COVID-19 can be more complex than we first expected. In February 2020, I was working as an infectious disease physician and had offered to deliver a card from my son’s class ...